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Beats 4 Everfree

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Everfree Northwest is a family friendly My Little Pony convention held in Seattle. They embrace the Elements of Harmony and the Magic of Friendship to which the show represents. This year, Lycan Dese Beats is dedicating an album to this wonderful convention, and we have called it Beats 4 Everfree! This is a charity album where all of the money raised will go towards their charity of choice for 2018, which this year is the Washington Autism Alliance Advocacy. Their mission is to ensure that all children and adults with Autism Spectrum Disorders (ASD’s) other developmental disabilities (DD’s) have every opportunity to thrive and become productive members of society. They do this by helping families access ASD DD health insurance benefits, effective services in schools, and supportive community-based services, regardless of their personal financial situation. This is a great charity and we encourage you to support them through this album. You aren’t under any obligation to donate, but if you choose to donate, we are certainly grateful. Acknowledgements: - The cover artwork done by Talons of Ice Fire. - All the musicians who submitted songs for ... the album. - Thank you to ExplodingPonyToast for all his help. - Release radio co-host DJT. - PonyvilleFM for hosting the live release. - And the Everfree Northwest 2018 convention. more
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An equation for the 1st Przybyłowski-Bollin conic is obtained by substituting -S for S.

X(11791) lies on these lines: {1,61}, {3,3196}, {9,10645}, {15,45}, {16,44}

See Antreas Hatzipolakis and Angel Montesdeoca Hyacinthos 25266

X(11792) lies on the nine-point circle and these lines: {113,3850}, {114,10276}, {128,10277}, {137,7668} et al

X(11792) = incentral-to-Feuerbach similarity image of X(11) X(11792) = Λ(antiorthic axis) wrt Feuerbach triangle X(11792) = X(8701)-of-orthic-triangle if ABC is acute

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X(11793) lies on these lines: {2,389}, {3,64}, {4,3917}, {5,141}, {20,7998}, {24,5651}, {30,5447}, {51,3090}, {52,1656}, {54,3292}, {68,5486}, {69,6804}, {140,9729}, {143,547}, {155,182}, {184,7509}, {185,631}, {264,8887}, {297,6750}, {373,3567}, {376,11381}, {381,10625}, {394,578}, {546,10627}, {549,5876}, {568,5070}, {632,5892}, {916,9940}, {960,2818}, {970,6911}, {1092,7503}, {1147,7514}, {1154,3628}, {1181,7484}, {1209,2072}, {1350,1598}, {1352,6643}, {1364,3074}, {1495,7512}, {1872,5784}, {2807,6684}, {2979,3091}, {3060,5056}, {3075,7066}, {3089,10519}, {3098,7387}, {3313,10516}, {3524,6241}, {3525,5890}, {3526,9730}, {3527,11477}, {3530,5663}, {3537,6225}, {3781,5709}, {3784,7330}, {3861,11017}, {4260,5707}, {5055,6243}, {5071,9781}, {5092,7516}, {5640,7486}, {5752,6918}, {5777,11573}, {5878,10996}, {5946,10219}, {6826,10441}, {7485,10984}, {7487,20002}, {10303,10574}

X(11793) = midpoint of X(i) and X(j) for these {i,j}: {3,5907}, {5,1216}, {140,11591}, {389,5562}, {546,10627}, {1352,11574}, {3819,5891}, {5446,6101}, {5777,11573} X(11793) = reflection of X(i) in X(j) for these (i,j): (389,11695), (3861,11017), (5462,3628), (5946,10219), (9729,140), (10110,5) X(11793) = complement of X(389) X(11793) = anticomplement of X(11695) X(11793) = X(12512)-of-orthic-triangle if ABC is acute X(11793) = {X(i),X(j)}-harmonic conjugate of X(k) for these (i,j,k): (2,389,11695), (2,5562,389), (2,11444,5562), (3,5891,5907), (3,9306,10282), (4,7999,3917), (5,6101,5446), (52,1656,5943), (155,7393,182), (185,5650,631), (394,7395,578), (631,11459,185), (632,6102,5892), (1092,7503,11430), (1216,5446,6101), (1216,10170,5), (3090,11412,51), (3567,5067,373), (3628,5462,6688), (3819,5907,3), (6643,11487,1352), (7485,11441,10984)

See Antreas Hatzipolakis and César Lozada Hyacinthos 25279

X(11794) lies on these lines: {110,9514}, {194,11002}, {2421,4576}, {3448,9513}, {3613,5169}

X(11794) = isogonal conjugate of X(3050) X(11794) = trilinear pole of the line X(5)X(141)

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X(11795) lies on this line: {1,7}

X(11795)

See Antreas Hatzipolakis and César Lozada Hyacinthos 25290

X(11796) lies on these lines: {1,9059}, {551,11717}

X(11796) = midpoint of X(1) and X(9059)

The other two types of fragment presentations, Murcko frameworks and Scaffold Tree, characterize molecular scaffolds, and they can represent the whole structural features for compounds in a library. Murcko frameworks, which are the union of ring systems (Fig. 1 a) and linkers (Fig. 1 b), are usually used as the structural signatures of molecules. As shown in Table 2 , the total numbers of the Murcko frameworks for all the standardized subsets except TCMCD do not have large difference, which may result from much more acylic molecules found in TCMCD, but those of the unique ones are quite different. The number of the unique Murcko frameworks for Mcule (27,247) is the highest, while that for TCMCD (12,941) is the lowest, highlighting the fact that the structures of natural compounds may be more conservative than those of the synthesized molecules in commercially available libraries. Other databases, such as ChemBridge and Enamine, also possess relatively high numbers of Murcko frameworks (25,788 and 26,870, respectively). However, as mentioned above, the diversity of the ring systems for Enamine is pretty low.

Fig.3

Rose maps for a the total numbers of the Scaffold Tree for the 12 datasets and b the non-duplicated numbers of the Scaffold Tree for the 12 datasets

In summary, TCMCD contains much more complicated structures and its whole molecular scaffolds are more conservative than the commercial libraries. Generally speaking, at Levels 2 and 3, ChemBridge and Mcule show high structural diversity. At Level 5 or higher, ChemicalBlock, Specs and VitasM possess relatively high structural diversity, suggesting that these libraries contain more complicated structures. LifeChemicals has relatively high diversity for the Scaffolds at Levels 3 and 4, but has relatively low diversity for rings, ring assemblies and bridge assemblies (Table 2 ). Certainly, in order to characterize the structural diversity of the 12 studied libraries more clearly, further quantitative analyses are necessary.

Fig.4

The scaled distributions of molecular weight for nine types of fragments found in the 12 datasets. Here, represents bridge assemblies, represents chain assemblies, Level_0, Level_1 and Level_2 represent Level 0, Level 1 and Level 2 of the Scaffold Tree, respectively, represents Murcko frameworks, represents rings, represents ring assemblies, and represents RECAP fragments

Fig.5

a Cumulative scaffold frequency curves of the Murcko frameworks, which is truncated at the point where the frequency of the fragment turns from 2 to 1, for the 12 dataset; b cumulative scaffold frequency curves of the Level 1 Scaffold Tree fragments, which is truncated at the point where the frequency of the fragment turns from 2 to 1, for the 12 datasets; c cumulative scaffold frequency plots (CSFPs) of the Murcko frameworks for the 12 datasets; d CSFPs of the Scaffold Tree fragments for the 12 datasets

Table4

PC50C values of the Murcko frameworks (Murcko) and Level 1 scaffolds for the 12 standardized datasets

The scaffold diversity evaluated based on the Level 1 scaffolds and Murcko frameworks deliver similar overall trends. Three libraries, including ChemDiv, Mcule and LifeChemicals, are more structurally diverse for whether the Level 1 scaffolds or Murcko frameworks, and two libraries, including TCMCD and Specs, are less structurally diverse. But the quantity statistics cannot reveal similarities among these scaffolds, and the scaffolds of TCMCD may present more diverse in similarity. Besides, the exact trends of CSFPs for the Murcko frameworks and Level 1 scaffolds are also different. The CSFPs for the Murcko frameworks are more discriminatory. It is possible that more granular Murcko frameworks enhance the apparent scaffold diversity. Moreover, PC50C is also just a simple index at a certain point in CSFPs. Therefore, a more comprehensive comparison within the distributions of the Level 1 scaffolds is necessary to evaluate the structural features of these libraries.

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